Reports state that Christina Applegate is looking ahead to the upcoming Screen Actors Guild Awards with bittersweet emotions.

The Dead to Me actress, who confirmed her MS diagnosis in 2021, revealed that the upcoming SAG Awards will most likely be her last as she continues to deal with the impacts from the disease.

"It's my last awards show as an actor probably, so it's kind of a big deal," Applegate, 51, told The Los Angeles Times in an interview published on Tuesday.

She added, "Right now, I couldn't imagine getting up at 5 a.m. and spending 12 to 14 hours on a set; I don't have that in me at this moment."

Applegate is nominated for outstanding performance by a female actor in a comedy series for her role as Jen Harding in the Netflix comedy. The nod marks her sixth-ever SAG nomination.

Though acting is no longer on her radar, Applegate does have her next career move in mind: "Doing a s— ton of voice-overs to make some cash to make sure that my daughter's fed and we're homed," she told the LA Times.